期刊
NANO RESEARCH
卷 12, 期 3, 页码 637-642出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-019-2271-5
关键词
positron emission tomography (PET) imaging; DNA nanotechnology; DNA tetrahedron nanoparticle; renal clearance; kidney dysfunction
类别
资金
- University of Wisconsin-Madison
- National Institutes of Health [NIBIB/NCI P30CA014520, T32CA009206]
- American Cancer Society [125246-RSG-13-099-01-CCE]
- National Natural Science Foundation of China [51573096, 51703132, 31771036, 81630049]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.
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