期刊
MONATSHEFTE FUR CHEMIE
卷 149, 期 12, 页码 2253-2263出版社
SPRINGER WIEN
DOI: 10.1007/s00706-018-2286-8
关键词
Amino acids; Cycloadditions; Heterocycles; MCF-7 cells; Apoptosis; Anti(myco)bacterial
资金
- Mersin University, Research Foundation [BAP 2015-AP2-1342]
A series of prolinate and N-amidocarbothiolprolinate derivatives based on a fused pyrrole-3,4-dione core, bearing indole ring systems, are prepared from the corresponding amino acid and an aldehyde via thermal 1,3-dipolar cycloaddition of azomethine ylides and condensation with benzoylisothiocyanate. Products are fully characterized by NMR, FT-IR, MS, and an X-ray crystal structure. The prepared compounds are screened for their antibacterial activity against a range of Gram-positive and Gram-negative bacteria and their antimycobacterial activity against M. tuberculosis H37Rv strain. In addition, two selected target compounds are evaluated for cytotoxicity, apoptosis, and anti-inflammatory effects on MCF-7 (breast carcinoma) cell lines. The incorporation of indole ring and -C(O)NHC(S)- moiety resulted to be beneficial since the biological point of view. [GRAPHICS]
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