期刊
MOLECULES
卷 23, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules23123250
关键词
Eryngium campestre; 17-membered ring lactone; cytotoxicity; Trypanosoma; Leishmania
资金
- Ministere des Affaires Etrangeres et du Developpement International
- Ministere de l'Europe et des Affaires Etrangeres
- European Funding [FEDER OBJ2142-3341]
The chemical composition of a hexanic extract of Eryngium campestre, obtained from its aerial parts, was investigated by GC-FID, GC/MS, HRMS, NMR and VCD analyses. The main compounds were germacrene D (23.6%), eudesma-4(15)-7-dien-1--ol (8.2%) and falcarindiol (9.4%), which are associated with a new uncommon and naturally found 17-membered ring lactone. This 17-membered ring features conjugated acetylenic bonds, named campestrolide (23.0%). The crude extract showed moderate antitrypanosomal (Trypanosoma brucei brucei), antileishmanial (Leishmania mexicana mexicana) and anticancer (cancerous macrophage-like murine cells) activities, and also displayed cytotoxicity, (human normal fibroblasts) in similar concentration ranges (IC50 = 3.0, 3.9, 4.0 and 4.4 mu g/mL respectively). Likewise, campestrolide displayed low activity on all tested cells (IC50: 12.5-19.5 mu M) except on Trypanosoma, on which it was very active and moderately selective (IC50 = 2.2 mu M. SI= 8.9). In conclusion, the new compound that has been described, displaying a singular structure, possesses interesting antitrypanosomal activity that should be further investigated and improved.
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