期刊
MOLECULES
卷 23, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules23123205
关键词
ERCC1; XPF; DSB repair; ICL repair; NER; DNA damage response; Fanconi anemia
资金
- Netherlands Foundation for Scientific Research (NWO-CW)
- European Commission (iNEXT project) [653706]
- European Commission (Instruct-ULTRA project) [731005]
- European Commission (Bio-NMR project) [261863]
Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.
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