期刊
MOLECULES
卷 24, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/molecules24010172
关键词
click chemistry; metabolic glycoengineering; cell surface modification; drug delivery; cancer therapy; cell tracking
资金
- Japan Society for the Promotion of Science (JSPS) [15K18850]
- Grants-in-Aid for Scientific Research [15K18850] Funding Source: KAKEN
Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. The recent development of copper-free and less cytotoxic click chemistry reactions has allowed for the application of click chemistry to the field of medicine. Moreover, metabolic glycoengineering allows for the direct modification of living cells with substrates for click chemistry either in vitro or in vivo. As such, click chemistry has become a powerful tool for cell transplantation and drug delivery. In this review, we describe some applications of click chemistry for cell engineering in cell transplantation and for drug delivery in the diagnosis and treatment of diseases.
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