期刊
MOLECULAR PHARMACEUTICS
卷 16, 期 2, 页码 709-723出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.8b01011
关键词
poly[2-(tert-butylamino)ethyl methacrylate]; polylactide; antimicrobial composites; atom transfer radical polymerization; heat treatment
资金
- Ministry of Science and Technology of Taiwan, Republic of China [MOST 106-2221-E-224-058, MOST 106-2113-M-039-002-MY2, MOST 107-2221-E-224-059-MY2, MOST 107-2632-E-035-001]
- Hong Kong Polytechnic University (Project Grant, G-YBMY)
Poly[2-(tert-butylaminoethyl) methacrylate] (PTA), an important class of antimicrobial polymers, has demonstrated its great biocidal efficiency, favorable nontoxicity, and versatile applicability. To further enhance its antimicrobial efficiency, an optimization of the chemical structure of PTA polymers is performed via atom transfer radical polymerization (ATRP) in terms of the antimicrobial ability against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). After the optimization, the resulting PTA is blended into a polylactide (PLA) matrix to form PTA/PLA composite thin films. It is first found, that the antimicrobial efficiency of PTA/PLA composites was significantly enhanced by controlling the PLA crystallinity and the PLA spherulite size. A possible mechanistic route regarding this new finding has been rationally discussed. Lastly, the cytotoxicity and mechanical properties of a PTA/PLA composite thin film exhibiting the best biocidal effect are evaluated for assessing its potential as a new material for creating antimicrobial biomedical devices.
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