期刊
MOLECULAR MICROBIOLOGY
卷 111, 期 2, 页码 303-316出版社
WILEY
DOI: 10.1111/mmi.14167
关键词
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资金
- French Research National Agency [ANR-16-CE12-0029-01, ANR-17-CE11-0038-02]
- Centre National de la Recherche Scientifique
- Aix-Marseille Universite
- Agence Nationale de la Recherche (ANR) [ANR-17-CE11-0038] Funding Source: Agence Nationale de la Recherche (ANR)
Thanks to the exponentially increasing number of publicly available bacterial genome sequences, one can now estimate the important contribution of integrated viral sequences to the diversity of bacterial genomes. Indeed, temperate bacteriophages are able to stably integrate the genome of their host through site-specific recombination and transmit vertically to the host siblings. Lysogenic conversion has been long acknowledged to provide additional functions to the host, and particularly to bacterial pathogen genomes where prophages contribute important virulence factors. This review aims particularly at highlighting the current knowledge and questions about lysogeny in Salmonella genomes where functional prophages are abundant, and where genetic interactions between host and prophages are of particular importance for human health considerations.
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