期刊
MOLECULAR MEDICINE REPORTS
卷 19, 期 2, 页码 771-782出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2018.9721
关键词
long non-coding RNA; colon cancer-associated transcript 1; cancer; oncogene; diagnosis; prognosis
资金
- Project of Standard Diagnosis and Treatment of Key Disease of Jiangsu Province [BE2015722]
- Project of the peak of the six talents of Jiangsu Province [WSN-018]
- Scientific Research Foundation for Health of Jiangsu Province [H201408]
Long non-coding RNAs (lncRNAs) have been classically defined as regulatory RNA members >200 nucleotides in length, without detectable open-reading frames to encode proteins. Previous studies have demonstrated that lncRNAs serve critical roles in multiple cancer types. Colon cancer-associated transcript 1 (CCAT1), a novel cancer-associated lncRNA, is significantly overexpressed in a number of malignancies. Functionally, as an oncogenic lncRNA, CCAT1 is involved in proliferation, migration, cell cycle progression, apoptosis, chemoresistance and other biological processes of cancer cells through complex regulation mechanisms in the cytoplasm or nucleus. In clinical applications, CCAT1 is additionally positively associated with histological differentiation, tumour node metastasis stage, vascular invasion, overall survival and recurrence-free survival, which demonstrates its important role as a diagnostic and prognostic marker in cancer. The present review summarises the current research progress of the oncogenic potential and clinical uses of CCAT1 in various human cancer types.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据