期刊
MOLECULAR IMMUNOLOGY
卷 105, 期 -, 页码 55-61出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2018.11.013
关键词
iNKTs; Subsets; NKT17; ROR gamma t; IL-17; Epigenetics; Transcription; Immune function
资金
- University of North Carolina (UNC) Lineberger Comprehensive Cancer Center (LCCC)
Invariant natural killer T cells (iNKTs) are distinct from conventional T cells. iNKT cells express a semi-invariant T cell receptor (TCR) that can specifically recognize lipid antigens presented by CD1d, an MHC class I-like antigen-presenting molecule. Currently, iNKT cells are distinguished in three functionally distinct subsets. Each subset is defined by lineage-specifying factors: T-bet shapes the fate of NKT1 subset that mainly secretes IFN gamma, Gata3 specifies the NKT2 subset that produces robustly IL-4 whereas ROR gamma t seals the differentiation of NKT17 subset that secretes IL-17. In the present review, the focus is placed on the regulation of NKT17 specification and their function.
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