期刊
MOLECULAR CELL
卷 73, 期 1, 页码 61-+出版社
CELL PRESS
DOI: 10.1016/j.molcel.2018.10.028
关键词
-
资金
- NSF Graduate Research Fellowship
- Ruth L. Kirschstein National Research Service Award [F31 CA203228-02]
- NIH [5R01CA163915-04]
- NIH Javits Neuroscience Investigator Award [R37 NS046789-12]
- CDMRP Breast Cancer Research Breakthrough Award
- Simons Foundation Autism Research Initiative
- Howard Hughes Medical Institute
Recent studies have indicated that nucleosome turnover is rapid, occurring several times per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we investigated H3K79 methylation, which is produced by a single methyltransferase (Dot1l) with no known demethylase. Using chemical-induced proximity (CIP), we find that the valency of H3K79 methylation (mono-, di-, and tri-) is determined by nucleosome turnover rates. Furthermore, propagation of this mark is predicted by nucleosome turnover simulations over the genome and accounts for the asymmetric distribution of H3K79me toward the transcriptional unit. More broadly, a meta-analysis of other conserved histone modifications demonstrates that nucleosome turnover models predict both valency and chromosomal propagation of methylation marks. Based on data from worms, flies, and mice, we propose that the turnover of modified nucleosomes is a general means of propagation of epigenetic marks and a determinant of methylation valence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据