期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 483, 期 -, 页码 64-73出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2019.01.006
关键词
BPS; EZRIN; POLARITY; Proliferation; PCOS
资金
- National Research Council of Argentina (CONICET)
- National Cancer Institute of Argentina (INC)
- National Atomic Energy Commission of Argentina (CNEA)
The use of Bisphenol S (BPS) was proposed as an alternative to Bisphenol A (BPA), a chemical employed in the production of polycarbonate plastics and epoxy resins. BPA is a xenoestrogen that affects normal physiology in several species. It was reported that BPS may also act as a xenoestrogen with harmful effects in the reproductive system. Here we studied the effects of BPS during the induction of a polycystic ovarian syndrome (PCOS)-like condition in rats. Animals were injected daily with vehicle, DHEA 60 mg/kg, BPS 1 mu g/kg and DHEA-BPS, for 20 days. Cell apoptosis, cell proliferation, and EZRIN expression were analyzed by immunohistochemistry. We found an increase in PCNA expression, which correlates with cytoplasmic accumulation of the polarization marker, EZRIN, in the BPS treated groups. Additionally, the administration of BPS in the DHEA treated group augmented the stratification and number of intraepithelial lumina in the endometrial surface epithelium.
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