期刊
MODERN RHEUMATOLOGY
卷 29, 期 2, 页码 226-230出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14397595.2018.1537962
关键词
Human immunology project; IgG4; plasmablast; Tfh cell; Treg cell
类别
资金
- Ministry of Health, Labor and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan [JSPS KAKENHI 15K08790, 17K16218]
- University of Occupational and Environmental Health, Japan, through UOEH Grant for Advanced Research
- Grants-in-Aid for Scientific Research [17K16218] Funding Source: KAKEN
As stated in the comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), IgG4-RD is characterized by elevated serum IgG4 level and pathological findings, characterized by infiltration of IgG4-positive plasma cells. In addition to fibrotic changes, dysregulated activation of lymphocytes is considered as one of major pathogenic events in IgG4-RD. Among lymphocytes, the importance of plasmablast, T follicular helper (Tfh) cells, T type 2 helper (Th2) cells, T regulatory (Treg) cells, and CD4 positive T cells with cytotoxic activity has been reported. Conversely, comprehensive immunophenotyping in patients with IgG4-RD revealed that there are two different axes consisting plasmablast-Tfh cells and Treg cells. There is need for research to seek out molecules associated with these immunocompetent cell interactions. It is believed that this will contribute to the future application to disease-specific treatment for IgG4-RD.
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