Spring support electromagnetic induction-based detection sensor for the coagulation process

Coagulation detection is a vital check item for patients undergoing surgery, and those with immunological disease and cardiovascular disease in clinic. Exploring the dynamic detection of the whole coagulation process has long been the research hotspot of experts and scholars. This study had proposed a novel electromagnetic type coagulation detector, which used the round and leaf spring as the middle spring support, with dynamic testing sensor technology of coagulation in vitro as the research objective. The vibration system constituted by support spring and electromagnetic induction device was theoretically analyzed through dynamic modeling of sensor. We conducted modal analysis and harmonic response analysis on the spring support group using finite element method, optimized the analysis results, manufactured the sensor experimental prototype, and constructed the coagulation testing device. We also tested the velocity spectral characteristics and displacement spectral characteristics of the sensor prototype, established the standard curve of POCT (point-of-care testing, POCT) in the rapid detection of coagulation through matching the coagulation testing device with coagulation reagent, and compared its methodology with the imported POCT coagulometer system. Our results suggested that, the vibration velocity of the sensor designed in this study was 1.5 mu m/s, and the amplitude was 1.75x10(-3) mu m. The correlation with the imported POCT coagulometer system in terms of test results was as high as 0.996, and the repeatability was 0.002. This study can provide theory and experimental foundation for the electromagnetic vibration induction technology in coagulation detection.