期刊
MICROCHIMICA ACTA
卷 186, 期 2, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-018-3115-9
关键词
In situ hydrothermal reaction; Bio-MOF-1; Open tubular column; Drug analysis; Nonsteroidal anti-inflammatory drugs; Sulfa drugs; Biomolecules; Electrochromatographic separation
资金
- National Natural Science Foundation of China [81872828, 81573384]
This work reportson the in-situ growth of a metal organic framework (MOF) composed of zinc(II), adeninate and biphenyldicarboxylate on the inner wall of a capillary, and theuse of this MOF as a stationary phases in open-tubular capillary electrochromatography. The inner wall of a fused-silica capillary was first modified with 3-aminopropyltriethoxysilane to create surface amino sites, and then the MOF was synthesized by in-situ growth. The modified capillary was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction. The results proved the successful growth of the MOF. The resultant open-tubular column showed good separation selectivity towards neutral compounds, acidic and basic compounds including nonsteroidal anti-inflammatory drugs, sulfa drugs and small biomolecules. In addition, the modified column is stable and repeatable. The precisions (expressed as RSDs) of the retention time for intra-day (n=5) and inter-day (n=5) separations and between columns (n=3) are less than 0.5, 1.6 and 4.7%, respectively. Conceivably, this new kind of MOF represents a most useful novel stationary phase in electrochromatographic separations.
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