期刊
MICROCHIMICA ACTA
卷 185, 期 12, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-018-3100-3
关键词
Photoelectrochemistry; Immunosensor; CEA; Transition metal dichalcogenides; Nanosheets; Gold nanoparticles
资金
- National Natural Science Foundation of China [21874157, 21675175, 21445003, 21275166]
- Major Projects of Technical Innovation of Hubei Province [2017ACA172]
- Natural Science Foundation of Hubei Province [2018CFB617, 2015CFA092]
Tungsten disulfide (WS2) nanosheets were obtained by exfoliating WS2 bulk crystals in N-methylpyrrolidone by ultrasonication. Gold nanoparticles (GNPs) were synthesized by in-situ ultrasonication of sodium citrate and HAuCl4 while fabricating the WS2 nanosheets. In this way, the GNPs were self-assembled on WS2 nanosheets to form a GNPs/WS2 nanocomposite through interaction between sulfur and gold atoms. The photoelectrochemical response of WS2 nanosheets is significantly enhanced after integration of the GNPs. The GNPs/WS2 nanocomposite was coated onto a glassy carbon electrode (GCE) to construct a sensing interface which then was modified with an antibody against the carcinoembryonic antigen (CEA) to obtain a photoelectrochemical immunosensor for CEA. Under optimized conditions, the decline in relative photocurrent is linearly related to the logarithm of the CEA concentration in the range from 0.001 to 40ngmL(-1). The detection limit is 0.5pgmL(-1) (at S/N=3). The assay is sensitive, selective, stable and reproducible. It was applied to the determination of CEA in clinical serum samples.
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