期刊
MICROCHIMICA ACTA
卷 186, 期 2, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-018-3139-1
关键词
Diazocoupling reaction; Thiol functional group; Magnetic packed column; Array chip-based MSPME; On-line analysis; ICP-MS; Throughput; GSH-1Areference material; Cell; Urine
资金
- National Nature Science Foundation of China [21775113, 21575107, 21375097, 21575108]
- Science Fund for Creative Research Groups of NSFC [20921062]
- MOE of China
- Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University [LF20181063]
A chip-based array is described for magnetic solid-phase microextraction (MSPME) of the ions of Pt, Au and Bi. Magnetic porous organic polymers (MOPs) prepared from magnetite nanoparticles and 1,3,5-tris(4-aminophenyl)benzene are introduced as a novel adsorbent. Eight solid phase extraction columns packed with MOPs were integrated in parallel on a microfluidic chip for array microextraction. After elution with a12% (m/v)solution of cysteamine hydrochloride (pH8.0), the eluent is introduced into an ICP-MS instrument for quantification. Under the optimized conditions, the limits of detection for Pt, Au and Bi are 8.6, 4.4 and 3.4ngL(-1), respectively. The sample throughput is 7h(-1), and the adsorption capacities are 32, 24 and 24gmg(-1) for Pt, Au and Bi, respectively. The method was validated by the determination of Bi in acertified reference material (GSH-1A; human hair), and the values obtained coincided with the certified value. This method was also applied to the determination of Pt, Au and Bi in (spiked) urine and cell samples, and good recoveries (85.8-113%) were achieved. The method is highly sensitive and has a high throughput and a low sample/reagent consumption (with 500 HeLa cells consumed).
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