期刊
MICROCHIMICA ACTA
卷 186, 期 1, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-018-3128-4
关键词
Metal-organic frameworks; Metal nanoparticles; Electrochemistry; Non-enzymatic sensor; Glassy carbon electrode; Cyclic voltammetry; Differential pulse voltammetry; Electrochemical impedance spectroscopy; Human serum; Standard addition method
资金
- NSF of China [21671049, 51572063, 21603113, 21701037]
- postdoctoral science foundation, China [2017M611380]
A Cr-based metal-organic framework MIL-101(Cr) was used to load platinum nanoparticles (PtNPs) that were placed on a glassy carbon electrode (GCE). The modified GCE was used as a non-enzymatic xanthine sensor. Compared to bare GCE, it requires a strongly decreased working potential and an increased signal current for xanthine oxidation. This is due to the crystalline ordered structure and large specific surface of the MIL-101(Cr), and to the high conductivity of the Pt NPs. Differential pulse voltammetry (DPV) shows the sensor to have a wide linear range (0.5 - 162M), a low detection limit (0.42M), and high selectivity. It was applied to the simultaneous determination of dopamine, uric acid, xanthine and hypoxanthine at working potentials of 0.13, 0.28, 0.68 and 1.05V, respectively (vs. Ag/AgCl) and to quantify xanthine in spiked serum samples.
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