期刊
MICROBIOLOGY-SGM
卷 165, 期 3, 页码 324-333出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000772
关键词
biofilm formation; Pseudomonas aeruginosa; c-di-GMP; cAMP; virulence factors
类别
资金
- Danish Council for Independent Research
- Danish Agency for Science and Higher Education
- Lundbeck Foundation
The human pathogen Pseudomonas aeruginosa can cause both acute infections and chronic biofilm-based infections. Expression of acute virulence factors is positively regulated by cAMP, whereas biofilm formation is positively regulated by c-di-GMP. We provide evidence that increased levels of cAMP, caused by either a lack of degradation or increased production, inhibit P. aeruginosa biofilm formation. cAMP-mediated inhibition of P. aeruginosa biofilm formation required Vfr, and involved a reduction of the level of c-di-GMP, as well as reduced production of biofilm matrix components. A mutant screen and characterization of defined knockout mutants suggested that a subset of c-di-GMP-degrading phosphodiesterases is involved in cAMP-Vfr-mediated biofilm inhibition in P. aeruginosa.
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