期刊
MICROBIAL PATHOGENESIS
卷 125, 期 -, 页码 393-400出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2018.10.004
关键词
Biofilm; Gold-complexed sulfonamides; PA01; LasR
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Conselho Nacional de Desenvolvimento Cientifico e Tecnoltigico
The antibacterial activity of sulfadiazine Au-PPh3, sulfadiazine Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3, sulfamethoxazole Ph2P-Au-Au-PPh2, sulfamethoxazole Au-PPh3 were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.
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