期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 92, 期 -, 页码 170-192出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2018.10.010
关键词
Liraglutide; Lorcaserin; Naltrexone/bupropion; Obesity; Orlistat; Personalized therapy phentermine/topiramate
资金
- Stavros Niarchos Foundation
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [389891681 (PE 2431/2-1)]
Obesity is a chronic disease with a continuously rising prevalence that currently affects more than half a billion people worldwide. Energy balance and appetite are highly regulated via central and peripheral mechanisms. and weight loss triggers a homeostatic response leading to weight regain. lifestyle and behavioral modifications are the cornerstones of obesity management; however, they often fail to achieve or sustain long-term weight loss. Pharmacotherapy added onto lifestyle modifications results in an additional, albeit limited, weight reduction. Regardless, this weight reduction of 5-10% conveys multiple cardiovascular and metabolic benefits. In this review, evidence on the food and drug administration (FDA)-approved medications, i.e., orlistat, lorcaserin, phentermine/topiramate, liraglutide and naltrexone/bupropion, is summarized. Furthermore, anti-obesity agents in the pipeline for potential future therapeutic use are presented. (C) 2018 Elsevier Inc. All rights reserved.
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