期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 1, 页码 92-100出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b11001
关键词
DNA origami; graphene; hybrid nanopore; DNA detection; pore functionalization; multiplex signal; dwell time
资金
- AFOSR [FA9550-12-1-0464]
- NSF [1264282, 1420882, 1506619, 1545907]
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1420882] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1264282] Funding Source: National Science Foundation
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [1506619] Funding Source: National Science Foundation
DNA,origami nanostructures can be used to furictionalize solid-state nanopores for single molecule, studies. In this study, we characterized a nanopore in a DNA origami-graphene heterostructure for DNA detection. The DNA origami nanopore is functionalized with a specific nucleotide type at the edge of the pore. Using extensive molecular dynamics (MD) simulations, we computed and analyzed the ionic conductivity of nanopores in heterostructures carpeted with one or two layers of DNA origami on graphene. We demonstrate that a nanopore in DNA origami graphene gives rise to distinguishable dwell times for the four DNA base types, whereas for a nanopore in bare graphene, the dwell time is almost the same for all types of bases. The specific interactions (hydrogen bonds) between DNA origami and the translocating DNA strand yield different residence times and ionic currents. We also conclude that the speed of DNA translocation decreases due to the friction between the dangling bases at the pore mouth and the sequencing DNA strands.
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