期刊
MEDICINE
卷 97, 期 50, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000013615
关键词
acute myocardial infarction; biomarkers; Glasgow Prognostic Score; mortality
资金
- Science Foundation of Science and Technology Department of Chengdu [2016-HM02-00099-SF]
- Science Foundation of Science and Technology Department of Sichuan [2018RZ0139, 2018JY0577, 2017SZ0190]
- Ministry of Science and Technology - National Key Projects [2017YFC0908702]
- Health and Family Planning Commission of Sichuan Province [16PJ305]
The inflammation-based Glasgow Prognostic Score (GPS), which involves C-reactive protein and serum albumin levels, has been reported to be a strong independent predictor of mortality in many cancers. This study aimed to investigate whether the GPS is associated with mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). In this study, 406 consecutive patients with STEMI at our emergency department (ED) who were undergoing pPCI were prospectively enrolled and assigned a GPS of 0, 1, or 2. Kaplan-Meier survival and multivariable Cox regression analyses were used to evaluate the associations between the GPS and long-term mortality. Twenty-three patients (5.7%) died at the hospital, and 37 (9.7%) died during follow-up (14.4 [9.3-17.6] months). Compared with patients with a lower GPS, those with a higher GPS had significantly higher in-hospital mortality (GPS=0 vs GPS=1 vs GPS=2: 3.3% vs 6.3% vs 28.0%, P<.001), follow-up mortality (4.6% vs 14.3% vs 55.6%, P<.001), and cumulative mortality (9.6% vs 21.1% vs 71.1%, P<.001). Multivariable Cox regression analysis revealed that in patients with a GPS of 1 and 2 (versus 0), the multivariable adjusted hazard ratios (HR) for all-cause mortality were 2.068 (95% CI: 1.082-3.951, P=.028) and 8.305 (95% CI: 4.017-17.171, P<.001), respectively, after controlling for all of the confounding factors. Subgroup analysis showed that a higher GPS was associated with an increased risk of cumulative mortality in the different subgroups. The GPS on admission may be useful for stratifying the risk of adverse outcomes in patients with STEMI undergoing pPCI in the ED.
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