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Lan Xiang et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)
Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort
Theodore M. Brasky et al.
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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
Jun Yoshino et al.
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Telomeres, lifestyle, cancer, and aging
Masood A. Shammas
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2011)
Bioavailability and antioxidant potential of rooibos flavonoids in humans following the consumption of different rooibos formulations
Till Breiter et al.
FOOD CHEMISTRY (2011)
The Phytochemical Glaucarubinone Promotes Mitochondrial Metabolism, Reduces Body Fat, and Extends Lifespan of Caenorhabditis elegans
K. Zarse et al.
HORMONE AND METABOLIC RESEARCH (2011)
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Eugenia Morselli et al.
JOURNAL OF CELL BIOLOGY (2011)
Diversity of Polyphenol Action in Caenorhabditis elegans: Between Toxicity and Longevity
Nadine Saul et al.
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Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
Hongwei Si et al.
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Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Richard A. Miller et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Curcumin-mediated lifespan extension in Caenorhabditis elegans
Vivian Hsiu-Chuan Liao et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2011)
Effect of ω-3 fatty acids on life span
Jing X. Kang
NUTRITION (2011)
Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice
Tsuyoshi Tsuduki et al.
NUTRITION (2011)
Curcumin improves insulin resistance in skeletal muscle of rats
L-X. Na et al.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2011)
Liver-Derived IGF-I Regulates Mean Life Span in Mice
Johan Svensson et al.
PLOS ONE (2011)
Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
Mitsuharu Matsumoto et al.
PLOS ONE (2011)
Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans
Wai-Jiao Cai et al.
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FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity
Alex Lublin et al.
PLOS ONE (2011)
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Tony Tiganis
TRENDS IN PHARMACOLOGICAL SCIENCES (2011)
SRT1720 improves survival and healthspan of obese mice
Robin K. Minor et al.
SCIENTIFIC REPORTS (2011)
The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials
Igho Onakpoya et al.
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Total mortality risk in relation to use of less-common dietary supplements
Gaia Pocobelli et al.
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Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease
Mohd. Moshahid Khan et al.
BRAIN RESEARCH (2010)
SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells
Yi Zu et al.
CIRCULATION RESEARCH (2010)
Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats
Dan-Li Yang et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2010)
AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol
Jee-Hyun Um et al.
DIABETES (2010)
Resveratrol protects against experimental stroke: Putative neuroprotective role of heme oxygenase 1
Yoshihito Sakata et al.
EXPERIMENTAL NEUROLOGY (2010)
Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity
Jun Lu et al.
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The Longevity Effect of Tannic Acid in Caenorhabditis elegans: Disposable Soma Meets Hormesis
Nadine Saul et al.
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Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar et al.
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Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Brian Onken et al.
PLOS ONE (2010)
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Shin-ichiro Imai
PHARMACOLOGICAL RESEARCH (2010)
Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster
Kyu-Sun Lee et al.
REJUVENATION RESEARCH (2010)
Extending Healthy Life Span-From Yeast to Humans
Luigi Fontana et al.
SCIENCE (2010)
Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats
Robin K. Minor et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
E. Morselli et al.
CELL DEATH & DISEASE (2010)
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Viviana I. Perez et al.
AGING CELL (2009)
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
J. Mark Davis et al.
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Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells
Teayoun Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43
Kerstin Pietsch et al.
BIOGERONTOLOGY (2009)
Neuroprotective Effects of (-)-Epigallocatechin-3-gallate on Aging Mice Induced by D-Galactose
Miao He et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2009)
The lifespan-promoting effect of acetic acid and Reishi polysaccharide
Ming-Hong Chuang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of ReIA Acetylation
Kyung-Chul Choi et al.
CANCER RESEARCH (2009)
Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression
Seung-Jae Lee et al.
CELL METABOLISM (2009)
New Users of Metformin Are at Low Risk of Incident Cancer A cohort study among people with type 2 diabetes
Gillian Libby et al.
DIABETES CARE (2009)
Black tea theaflavins extend the lifespan of fruit flies
Cheng Peng et al.
EXPERIMENTAL GERONTOLOGY (2009)
Bioavailability of C-Linked Dihydrochalcone and Flavanone Glucosides in Humans Following Ingestion of Unfermented and Fermented Rooibos Teas
Angelique Stalmach et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)
Regulation of Autophagy by the p300 Acetyltransferase
In Hye Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms
Richard A. Miller
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg et al.
NATURE CELL BIOLOGY (2009)
A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan
Ayumi Shibamura et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Catechin induced longevity in C. elegans: From key regulator genes to disposable soma
Nadine Saul et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
Saravanan S. Karuppagounder et al.
NEUROCHEMISTRY INTERNATIONAL (2009)
Epigallocatechin Gallate from Green Tea (Camellia sinensis) Increases Lifespan and Stress Resistance in Caenorhabditis elegans
Sami Abbas et al.
PLANTA MEDICA (2009)
Association of FOXO3A variation with human longevity confirmed in German centenarians
Friederike Flachsbart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Antioxidants prevent health-promoting effects of physical exercise in humans
Michael Ristow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Chong Chen et al.
SCIENCE SIGNALING (2009)
Remarkable longevity and stress resistance of nematode PI3K-null mutants
Srinivas Ayyadevara et al.
AGING CELL (2008)
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Randy Strong et al.
AGING CELL (2008)
Berberine improves glucose metabolism through induction of glycolysis
Jun Yin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)
Reserpine can confer stress tolerance and lifespan extension in the nematode C-elegans
Deepti Srivastava et al.
BIOGERONTOLOGY (2008)
Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats
Jean-Francois Bisson et al.
BRITISH JOURNAL OF NUTRITION (2008)
Metformin slows down aging and extends life span of female SHR mice
Vladimir N. Anisimov et al.
CELL CYCLE (2008)
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
Ying Li et al.
CELL METABOLISM (2008)
Stress-response hormesis and aging: That which Does Not Kill Us Makes Us Stronger
David Gems et al.
CELL METABOLISM (2008)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
Kevin J. Pearson et al.
CELL METABOLISM (2008)
AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism
C. A. Witczak et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
Andreas Kampkoetter et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2008)
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes
Steven Russell Fauce et al.
JOURNAL OF IMMUNOLOGY (2008)
Creatine improves health and survival of mice
A. Bender et al.
NEUROBIOLOGY OF AGING (2008)
Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside
Susanne Kreuz et al.
NUTRITION RESEARCH (2008)
FOXO3A genotype is strongly associated with human longevity
Bradley J. Wilicox et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Yousin Suh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Metabolic adaptations through the PGC-1α and SIRT1 pathways
Joseph T. Rodgers et al.
FEBS LETTERS (2008)
Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte
Jin-Taek Hwang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans
Andreas Kampkoetter et al.
ARCHIVES OF TOXICOLOGY (2007)
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne et al.
NATURE (2007)
Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
Chih-Li Lin et al.
JOURNAL OF LIPID RESEARCH (2007)
Pancreatic lipase inhibitors from natural sources: unexplored potential
Rahul B. Birari et al.
DRUG DISCOVERY TODAY (2007)
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
Kenichi Kitani et al.
BIOGERONTOLOGY (2007)
The common biology of cancer and ageing
Toren Finkel et al.
NATURE (2007)
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention - Systematic review and meta-analysis
Goran Bjelakovic et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Jaemin Jeong et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2007)
Dietary lutein/zeaxanthin partially reduces photoaging and photocarcinogenesis in chronically UVB-irradiated Skh-1 hairless mice
S. Astner et al.
SKIN PHARMACOLOGY AND PHYSIOLOGY (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur et al.
NATURE (2006)
Beneficial effects of natural antioxidants EGCG and α-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
Marishka K. Brown et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)
The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
Coleen T. Murphy
EXPERIMENTAL GERONTOLOGY (2006)
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
Yun S. Lee et al.
DIABETES (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Chronic systemic D-Galactose exposure induces memory loss, neuro degeneration, and oxidative damage in mice:: Protective effects of R-α-lipoic acid
Xu Cui et al.
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Calorie restriction mimetics: an emerging research field
DK Ingram et al.
AGING CELL (2006)
Biology of longevity:: Role of the innate immune system
G Candore et al.
REJUVENATION RESEARCH (2006)
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
MA Wilson et al.
AGING CELL (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Caloric restriction in humans: Potential pitfalls and health concerns
AJ Dirks et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2006)
Therapeutic potential of resveratrol: the in vivo evidence
Joseph A. Baur et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
JT Hwang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Sir2 blocks extreme life-span extension
P Fabrizio et al.
CELL (2005)
Autophagy and aging -: The importance of maintaining clean cells
Ana Maria Cuervo et al.
AUTOPHAGY (2005)
Starvation in humans: Evolutionary background and contemporary implications
AM Prentice
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Effects of telomerase and telomere length on epidermal stem cell behavior
I Flores et al.
SCIENCE (2005)
Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice
L Li et al.
LIFE SCIENCES (2005)
A complex dietary supplement extends longevity of mice
JA Lemon et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)
Celastrol Blocks Neuronal Cell Death and Extends Life in Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Mahmoud Kiaei et al.
NEURODEGENERATIVE DISEASES (2005)
Minireview: Role of the growth hormone/insulin-like growth factor system in mammalian aging
A Bartke
ENDOCRINOLOGY (2005)
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet et al.
SCIENCE (2004)
Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet
JL Quiles et al.
EXPERIMENTAL GERONTOLOGY (2004)
An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster
JH Bauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
K Balasubramanyam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
B Rogina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A-SOD1 transgenic mice
M West et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
CT Murphy et al.
NATURE (2003)
A dietary supplement abolishes age-related cognitive decline on transgenic mice expressing elevated free radical processes
JA Lemon et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2003)
Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice
VN Anisimov et al.
EXPERIMENTAL GERONTOLOGY (2003)
Association between telomere length in blood and mortality in people aged 60 years or older
RM Cawthon et al.
LANCET (2003)
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
E Langley et al.
EMBO JOURNAL (2002)
Growth negatively impacts the life span of mammals
CD Rollo
EVOLUTION & DEVELOPMENT (2002)
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
GP Lim et al.
JOURNAL OF NEUROSCIENCE (2001)
Aspirin use and all-cause mortality among patients being evaluated for known or suspected coronary artery disease - A propensity analysis
PA Gum et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
Synergy and other interactions in phytomedicines
EM Williamson
PHYTOMEDICINE (2001)
Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice
K Okada et al.
JOURNAL OF NUTRITION (2001)
Melatonin increases both life span and tumor incidence in female CBA mice
VN Anisimov et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)