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Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
Paul V. Fish et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Interleukin-6: A multifunctional targetable cytokine in human prostate cancer
Zoran Culig et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Growth Inhibition of Ovarian Tumor-Initiating Cells by Niclosamide
Yi-Te Yo et al.
MOLECULAR CANCER THERAPEUTICS (2012)
The Impact of Point Mutations in the Human Androgen Receptor: Classification of Mutations on the Basis of Transcriptional Activity
Colin W. Hay et al.
PLOS ONE (2012)
Androgen receptor overexpression alters binding dynamics of the receptor to chromatin and chromatin structure
Alfonso Urbanucci et al.
PROSTATE (2012)
Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells
Jing-Xuan Pan et al.
CHINESE JOURNAL OF CANCER (2012)
Oxidative phosphorylation in cancer cells
Giancarlo Solaini et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2011)
Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
Brett S. Carver et al.
CANCER CELL (2011)
Small Molecule Inhibitors Targeting the Achilles' Heel of Androgen Receptor Activity
Marianne D. Sadar
CANCER RESEARCH (2011)
Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations
Takuya Osada et al.
CANCER RESEARCH (2011)
Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer
Medha S. Darshan et al.
CANCER RESEARCH (2011)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Disruption of androgen receptor signaling in males by environmental chemicals
Doug C. Luccio-Camelo et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2011)
Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer
Ulrike Sack et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)
Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway
Wenyan Lu et al.
PLOS ONE (2011)
Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production
F. L. Khanim et al.
BLOOD CANCER JOURNAL (2011)
Transcription Factor Stat3 Stimulates Metastatic Behavior of Human Prostate Cancer Cells in Vivo, whereas Stat5b Has a Preferential Role in the Promotion of Prostate Cancer Cell Viability and Tumor Growth
Lei Gu et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting-Group-Free Strategy
Zhenhua Gu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
Raymond J. Andersen et al.
CANCER CELL (2010)
Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species
Yanli Jin et al.
CANCER RESEARCH (2010)
Tubulin-Targeting Chemotherapy Impairs Androgen Receptor Activity in Prostate Cancer
Meng-Lei Zhu et al.
CANCER RESEARCH (2010)
Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo
Lei Gu et al.
ENDOCRINE-RELATED CANCER (2010)
The PPARγ ligand ciglitazone regulates androgen receptor activation differently in androgen-dependent versus androgen-independent human prostate cancer cells
Patrice E. Moss et al.
EXPERIMENTAL CELL RESEARCH (2010)
Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells
Huiqing Yuan et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)
Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
Pinar Uysal-Onganer et al.
MOLECULAR CANCER (2010)
Minireview: Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRAMs)
Terry W. Moore et al.
MOLECULAR ENDOCRINOLOGY (2010)
Selective inhibition of BET bromodomains
Panagis Filippakopoulos et al.
NATURE (2010)
Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway
Xiaomei Ren et al.
ACS MEDICINAL CHEMISTRY LETTERS (2010)
Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer
Lu Gan et al.
CANCER RESEARCH (2009)
Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells
Jae Yeon Chun et al.
CLINICAL CANCER RESEARCH (2009)
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
Bryan T. MacDonald et al.
DEVELOPMENTAL CELL (2009)
Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling
Aruna D. Balgi et al.
PLOS ONE (2009)
Non-competitive androgen receptor inhibition in vitro and in vivo
Jeremy O. Jones et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Chris Tran et al.
SCIENCE (2009)
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu et al.
NATURE REVIEWS CANCER (2009)
Stat3 promotes metastatic progression of prostate cancer
Junaid Abdulghani et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells
Marianne D. Sadar et al.
ORGANIC LETTERS (2008)
Live-cell analysis of mitotic spindle formation in taxol-treated cells
Jessica E. Hornick et al.
CELL MOTILITY AND THE CYTOSKELETON (2008)
Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells
Shankar Jagadeesh et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
A surface on the androgen receptor that allosterically regulates coactivator binding
Eva Estebanez-Perpina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Completion of a programmable DNA-binding small molecule library
Carey F. Hsu et al.
TETRAHEDRON (2007)
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
Nicholas G. Nickols et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Peroxisome proliferator-activated receptor γ-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation
Chih-Cheng Yang et al.
CANCER RESEARCH (2007)
The androgen receptor negatively regulates the expression of c-Met: Implications for a novel mechanism of prostate cancer progression
Meletios Verras et al.
CANCER RESEARCH (2007)
The synthetic androgen methyltrienolone (R1881) acts as a potent antagonist of the mineralocorticoid receptor
Armelle-Natsuo Takeda et al.
MOLECULAR PHARMACOLOGY (2007)
Improved nuclear localization of DNA-binding polyamides
Nicholas G. Nickols et al.
NUCLEIC ACIDS RESEARCH (2007)
Sensitivity of secondary structure propensities to sequence differences between α- and γ-synuclein:: Implications for fibrillation
Joseph A. Marsh et al.
PROTEIN SCIENCE (2006)
Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells
X. Yang et al.
ONCOGENE (2006)
Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins
B Devarakonda et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2005)
Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1
H Ooe et al.
TOXICOLOGICAL SCIENCES (2005)
Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations
DN Lavery et al.
BIOCHEMICAL JOURNAL (2005)
Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway
MK Roy et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
IFN unresponsiveness in LNCaP cells due to the lack of JAK1 gene expression
GP Dunn et al.
CANCER RESEARCH (2005)
Structural basis of androgen receptor binding to selective androgen response elements
PL Shaffer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Structural and functional consequences of glutamine tract variation in the androgen receptor
G Buchanan et al.
HUMAN MOLECULAR GENETICS (2004)
Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H- pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation
H Esumi et al.
CANCER SCIENCE (2004)
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
M Verras et al.
CANCER RESEARCH (2004)
An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP)
B He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60)
MK Roy et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Analysis of Wnt gene expression in prostate cancer: Mutual enhibition by WNT11 and the androgen receptor
HN Zhu et al.
CANCER RESEARCH (2004)
β-Catenin signaling in prostate cancer:: an early perspective
DR Chesire et al.
ENDOCRINE-RELATED CANCER (2003)
Recognition of the DNA minor groove by pyrrole-imidazole polyamides
PB Dervan et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2003)
The androgen receptor interacts with multiple regions of the large subunit of general transcription factor TFIIF
J Reid et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells
T Ueda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Antimutagenicity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutum
K Nakahara et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)
Stat3 activation in prostatic carcinomas
R Dhir et al.
PROSTATE (2002)
Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer
Y Segawa et al.
PROSTATE (2002)
Linking β-catenin to androgen-signaling pathway
FJ Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis
SF Shariat et al.
UROLOGY (2001)
Antioxidative activity of carbazoles from Murraya koenigii leaves
Y Tachibana et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)
FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor
B He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The role of STATs in transcriptional control and their impact on cellular function
J Bromberg et al.
ONCOGENE (2000)
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