期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 8, 页码 5148-5159出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b12212
关键词
cartilage regeneration; kartogenin; mesenchymal stem cells; thermogel; tissue engineering
资金
- National Natural Science Foundation of China [81171681, 51303174, 51233004, 51390484, 51321062, 51473165, 51203153, 51273196]
- National Science Foundation for Post-Doctoral Scientists of China [2013M530990]
- Scientific Development Program of Jilin Province [20140520050JH, 20140309005GX, 20130206058GX]
Recently, cartilage tissue engineering (CTE) attracts increasing attention in cartilage defect repair. In this work, kartogenin (KGN), an emerging chondroinductive nonprotein small molecule, was incorporated into a thermogel of poly(L-lactide-co-glycolide)-poly(ethylene glycol)-poly(L-lactide-co-glycolide) (PLGA-PEG-PLGA) to fabricate an appropriate rnicroenvironment of bone marrow mesenchymal stem cells (BMSCs) for effective cartilage regeneration. More integrative and smoother repaired articular surface, more abundant characteristic glycosaminoglycans (GAGS) and collagen II (COL II), and less degeneration of normal cartilage were obtained in the KGN and BMSCs coloaded thermogel group in vivo. In conclusion, the KGN-loaded PLGA-PEG-PLGA thermogel can be utilized as an alternative support for BMSCs to regenerate damaged cartilage in vivo.
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