期刊
MEDICAL ONCOLOGY
卷 36, 期 1, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-018-1223-3
关键词
IL-33; sST2; Cytokines; Pancreatic ductal adenocarcinoma; Chronic inflammation
类别
资金
- Burger-meisterfond der Stadt Wien [15063]
Interleukin-33 (IL-33) and its decoy receptor soluble ST2 (sST2) are involved in the development of chronic inflammation and cancer. We explored IL-33 and sST2 as a potential prognostic marker in patientswith metastatic and locally advanced pancreatic ductal adenocarcinoma (PDAC). IL-33 and sST2 plasma levels were assessed in 20 patients with advanced PDAC before start of systemic chemotherapy and were analyzed in relation to clinical outcome. Kaplan Meier and multivariable Cox proportional hazards model analysis revealed a significant association between sST2 plasma levels and survival (HR 2.10, 95% CI 1.33-3.41, p=0.002) and link high sST2 plasma levels to inferior survival in patients with advanced PDAC undergoing chemotherapy.
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