期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 3, 页码 2416-2422出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11741
关键词
mesoporous silica nanoparticles; phosphonate groups; MCF-7 cells; BJ cells; cell cycle; anticancer drugs
资金
- Singapore Ministry of Education (Tier 2 Grant) [R279-000-418-112, MOE2013-T2-2-093]
- Department of Chemical and Biomolecular Engineering, NUS
In this work, we synthesized pristine mesoporous silica nanoparticles (MSN) and functionalized these with phosphonate groups (MSN-Phos). We report, for the first time, cell death in MCF-7 cells (human breast adenocarcinoma cell line) when exposed to the empty MSN and MSN-Phos nanoparticles. In comparison, the same nanopartides were found to elicit few deleterious effects on normal human foreskin fibroblast cells (BJ cells). MCF-7 cells were found to exhibit a concentration-dependent uptake, whereas no detectable nanoparticle uptake was observed in the BJ cells, irrespective of treatment dosage. A disruption of the cell cycle in the MCF-7 cells was determined to be the cause of cell death from the nanoparticle exposure, thereby suggesting the role of nondrug loaded MSN and MSN-Phos as effective anticancer drugs.
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