期刊
MEDIATORS OF INFLAMMATION
卷 2018, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2018/4231591
关键词
-
资金
- Instituto Mexicano del Seguro Social [FIS/IMSS/PROT/PRIO/15/049, CTFIS/1ORD/012/2011]
- CONACYT [CB-2015-01 258123, 461456]
- IMSS [97220054]
- Fundacion IMSS, A.C.
Autophagy is a protein and organelle degradation pathway important for the maintenance of cytoplasmic homeostasis and for providing nutrients for survival in response to stress conditions. Recently, autophagy has been shown to be important for the secretion of diverse proteins involved in inflammation, intercellular signaling, and cancer progression. The role of autophagy in cancer depends on the stage of tumorigenesis, serving a tumor-suppressor role before transformation and a tumor-survival function once a tumor is established. We review recent evidence demonstrating the complexity of autophagy regulation during cancer, considering the interaction of autophagy with protein secretion pathways. Autophagy manipulation during cancer treatment is likely to affect protein secretion andinter-cellular signaling either to the neighboring cancer cells or to the antitumoral immune response. This will be an important consideration during cancer therapy since several clinical trials are trying to manipulate autophagy in combination with chemotherapy for the treatment of diverse types of cancers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据