期刊
MEDIATORS OF INFLAMMATION
卷 2018, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2018/8696543
关键词
-
资金
- Argentinean Agency for Promotion of Science and Technology [PICT V 2014-367, 2014-2320]
- Bunge & Born Foundation
- University of Buenos Aires Science and Technology [UBACyT 20020170100619BA]
- Allende Foundation
- National Academy of Medicine of Argentina
- National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA [HL121402, HL136816]
- Hospital Italiano de Buenos Aires
- Sales Foundation
Galectin-1 (Gal-1), an evolutionarily conserved beta-galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presenting cells. In addition, this lectin promotes angiogenesis by co-opting the vascular endothelial growth factor receptor (VEGFR) 2 signaling pathway. Since a coordinated network of immunomodulatory and proangiogenic mediators controls cardiac homeostasis, this lectin has been proposed to play a key hierarchical role in cardiac pathophysiology via glycan-dependent regulation of inflammatory responses. Here, we discuss the emerging roles of Gal-1 in cardiovascular diseases including acute myocardial infarction, heart failure, Chagas cardiomyopathy, pulmonary hypertension, and ischemic stroke, highlighting underlying anti-inflammatory mechanisms and therapeutic opportunities. Whereas Gal-1 administration emerges as a potential novel treatment option in acute myocardial infarction and ischemic stroke, Gal-1 blockade may contribute to attenuate pulmonary arterial hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据