期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 33, 页码 21193-21200出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b06136
关键词
photodynamic therapy; bioimaging; nanoparticles; aggregation-induced emission; theranostics
资金
- Singapore National Research Foundation [R-279-000-444-281]
- Institute of Materials Research and Engineering of Singapore [IMRE/14-8P1110]
We report a facile encapsulation approach to realize bright far red/near-infrared (FR/NIR) fluorescence and efficient singlet oxygen COD production of organic fluorogens with aggregation-induced emission (AIEgen) and intramolecular charge transfer (ICT) characteristics for image-guided photodynamic cancer cell ablation. The synthesized AIEgen BTPEAQ possesses donor-acceptor-donor structure, which shows bright fluorescence in solid state. Due to the strong ICT effect, BTPEAQ exhibits poor emission with almost no O-1(2) generation in aqueous solution. Encapsulation of BTPEAQ by DSPE-PEG block copolymer yields polymer-shelled dots, which show enhanced brightness with a fluorescence quantum yield of 3.9% and a O-1(2) quantum yield of 38%. Upon encapsulation by silica, the formed SiO2-shelled dots show much improved fluorescence quantum yield of 12.1% but with no obvious O-1(2) generation. This study clearly demonstrates the importance of encapsulation approach for organic fluorophores, which affects not only the brightness but also the O-1(2) production. After conjugating the polymer-shelled AIE dots with cRGD peptide, the obtained BTPEAQ-cRGD dots show excellent photoablation toward MDA-MB-231 cells with integrin overexpression while keeping control cells intact.
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