期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 18, 页码 11758-11764出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b01788
关键词
artificial cell membrane; biomimetics; hybrid materials; stimuli-responsive materials; surface modification; spatiotemporal and prompt gating; on-off gating
资金
- National Creative Research Initiative Program
- National Research Foundation of Korea - Korean Government [2013R1A3A2042196]
Stimuli-responsive polymers have been widely used for controlled release of several biomolecules. In general, a single stimulus among various stimuli, for instance, temperature, pH, or light, has been used for these polymers. Although some stimuli are applied together, one cannot control each stimulus independently at a given stimulus-responsive polymer. However, to mimic biological system like cell membrane, multiple on off gates utilizing independent control of dual (or multiple) stimuli should be used. Here, we introduce a stimuli-responsive membrane controlled by two orthogonal stimuli. For this purpose, the top and the bottom parts of anodized aluminum oxide membrane walls are independently grafted by thermoresponsive poly(N-isopropylacrylamide) and pH-responsive poly(acrylic acid), respectively, by using surface-initiated atom transfer radical polymerization. The membrane clearly showed two independent on off gates depending on temperature and pH. Furthermore, through light irradiation of two different wavelengths (near-infrared and ultraviolet), temperature and pH were also controlled independently and promptly. Thus, this membrane shows two independent on-off gating of the transport of a model biomolecule of fluorescein isothiocyanate-labeled bovine serum albumin. This strategy suggests the potential of independently modified membrane in layers as stimuli-responsive on off gates for the application of artificial cell membrane.
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