期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 24, 页码 15067-15075出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b03021
关键词
Ag/AgCl; graphene; oxidative radicals; antimicrobial properties; burn wound
资金
- National Natural Science Foundation of China [51572114]
- Six Personnel Peak Project of Jiangsu Province [2009137]
- Washington State University (WSU)
In recent years, researchers have proven the release of silver ions (Ag+) from silver nanoparticles (Ag NPs) significantly affects their toxicity to bacteria and other organisms. Due to the difficulty in maintaining a steady flux of a high concentration of Ag+, it is still challenging to develop a highly efficient, stable, and biocompatible Ag NP-based antimicrobial material. To circumvent this issue, we developed a new Ag-based bactericide through the fabrication of sunlight driven and ultrafine silver/silver chloride anchored on reduced graphene oxide (Ag/AgCl/rGO). This stable Ag/AgCl nanophotocatalyst with negligible release of Ag+ generated a high amount of oxidative radicals, killing the bacteria, thus achieving both high bactericidal efficiency and stability. Moreover, functionalization of the nanomaterial with poly(diallyldimethylammonium chloride) (PDDA) gives it a highly adsorptive capacity, which allows it to capture the bacteria and possibly enhances the bactericidal activity. In vivo histopathological studies showed that the Ag/AgCl/rGO nanomaterial could obviously promote the regeneration of the epidermis, which indicated the good biomedical potential of Ag/AgCl/rGO nanomaterial in burn wound healing.
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