期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 27, 页码 17038-17046出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b01147
关键词
Prussian blue; mesoporous silica; photoacoustic tomography; magnetic resonance imaging; photothermo-chemotherapy
资金
- National Key Basic Research Program of the PRC [2014CB744504, 2014CB744501]
- Major International (Regional) Joint Research Program of China [81120108013]
- National Natural Science Foundation of China [81201175, 81530054, 81501538, 81322020, 81230032, 81401468, 81501537]
- National Science Foundation for Postdoctoral Scientists of China [2014T71012, 2013M542576, 2013T60939, 2012M521934]
In this work, we design mesoporous silica-coated Prussian blue nanocubes with PEGyltation to construct multifunctional PB@ mSiO(2)-PEG nanocubes. The PB@mSiO(2)-PEG nanocubes have good biocompatibility, excellent photothermal transformation capacity, in vivo magnetic resonance and photoacoustic imaging ability. After loading antitumor drug doxorubicin (DOX) in the PB@mSiO(2)-PEG nanocubes, the constructured PB@mSiO(2)-PEG/DOX nanoplatforms show an excellent pH-responsive drug release character within 48 h, namely, an ultralow cumulative drug release amount of 3.1% at pH 7.4 and a high release amount of 46.6% at pH 5.0. Upon near-infrared laser irradiation, the PB@mSiO(2)-PEG/DOX nanoplatforms show an enhanced synergistic photothermal and chemical therapeutic efficacy for breast cancer than solo photothermal therapy or chemotherapy.
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