期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 94, 期 -, 页码 740-749出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.10.027
关键词
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资金
- National Center for International Joint Research of Micro-Nano Molding Technology
- China Scholarship Council (CSC)
- NIH NIDCD [R0104336]
- National Science Fund [11372286, 11372287]
- International Technological Cooperation Project [2015DFA30550]
- Wisconsin Institute for Discovery (WID)
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC004336] Funding Source: NIH RePORTER
Vocal fold tissue engineering requires biomimetic scaffolds with an appropriate matrix stiffness closely matching that of the natural vocal folds to maintain function. Traditionally, poly(epsilon-caprolactone) (PCL) and thermoplastic polyurethane (TPU) have been employed as the primary matrix materials for vocal fold electrospun scaffolds. However, not all of the scaffolds fabricated thus far matched the human vocal fold tissues. Poly(glycerol sebacate) (PGS) is a non-cytotoxic and biodegradable soft elastomer that has shown promising results for soft tissue engineering applications. However, no work has been done to employ this biomaterial to construct vocal fold scaffolds. In this study, PGS has been synthesized and blended with thermoplastic polyurethane (TPU) to produce vocal fold scaffolds with improved hydrophilicity and compliance by electrospinning. The resulting scaffolds were found to have mechanical properties mimicking those of the vocal fold lamina propria extracellular matrix (ECM). An unusual leaf-like structure was obtained when using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Other suitable fibrous scaffolds were also obtained when using acetic acid and 2,2,2-trifluoroethanol (TFE) as binary solvents. A biological evaluation of these TPU/PGS scaffolds showed better cell spreading and significantly improved cell proliferation as compared to TPU-only scaffolds (p < 0.01), thereby suggesting potential applications for vocal fold tissue engineering.
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