期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 2, 页码 1080-1086出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11445
关键词
microfiber; tissue engineering; cell-encapsulation; microfluidics; hydrogel
资金
- National Science Foundation of China [21473029, 91227124, 51522302]
- NASF Foundation of China [U1530260]
- National Science Foundation of Jiangsu [BK20140028]
- research Fund for the Doctoral Program of Higher Education of China [20120092130006]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1222]
- Program for New Century Excellent Talents in University
The fabrication of heterogeneous microstructures, which exert precise control over the distribution of different cell types within biocompatible constructs, is important for many tissue engineering applications. Here, bioactive microfibers with tunable morphologies, structures, and components are generated and employed for creating different tissue constructs. Multibarrel capillary microfluidics with multiple laminar flows are used for continuously spinning these microfibers. With an immediate gelation reaction of the cell dispersed alginate solutions, the cell-laden alginate microfibers with the tunable morphologies and structures as the designed multiple laminar flows can be generated. The performances of the microfibers in cell culture are improved by incorporating bioactive polymers, such as extracellular matrix (ECM) or methacrylated gelatin (GelMA), into the alginate. It is demonstrated that a series of complex three-dimensional (3D) architectural cellular buildings, including biomimic vessels and scaffolds, can be created using these bioactive microfibers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据