期刊
MASS SPECTROMETRY REVIEWS
卷 38, 期 3, 页码 253-264出版社
WILEY
DOI: 10.1002/mas.21581
关键词
peptidomics; biofluids; mass spectrometry; extraction; identification; neuropeptide
类别
Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context. After these hurdles are (partially) overcome, peptidomics will be ready for a successful translation into medical practice.
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