4.1 Article

Evidence of selective pressure in whale fall microbiome proteins and its potential application to industry

期刊

MARINE GENOMICS
卷 45, 期 -, 页码 21-27

出版社

ELSEVIER
DOI: 10.1016/j.margen.2018.11.004

关键词

Deep sea; Metagenomics; Marine bacteria

资金

  1. CAPES (Brazil) [CAPES/JSPS 02/13, 08740/14-3]
  2. FAPESC (Brazil) [3422/2012]
  3. CNPq -INCT-Mar COI (Brazil) [565062/2010-7]
  4. Santa Catarina State Govern (Brazl)
  5. CNPq (Brazil) [381573/2015-0, 311010/2015-6]

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The present study addresses the microbiome of the first whale fall (YOKO 16) that has been described in the deep sea in the southern Atlantic Ocean (Sao Paulo Plateau; 4204 m depth), in terms of its metabolic uniqueness. Sets of ten thousand protein sequences from YOKO 16 and 29 public domain metagenomes (SRA and GenBank databases) that represent various marine, terrestrial and gut-associated microbial communities were analyzed. The determination of protein functionality, based on the KAAS server, indicated that the YOKO 16 microbiome has industrially-relevant proteins, such as proteases and lipases, that have low similarity (similar to 50%) with previously-described enzymes. The amino acid usage in the YOKO 16 protein sequences (based on blastp and Clustal analysis) revealed a pattern of preference similar to that of extremophiles, with an increased usage of polar, charged and acidic amino acids and a decreased usage of nonpolar residues. We concluded that the targeted microbiome is of potential biotechnological use, which justifies the allocation of resources for the discovery of enzymes in deep-sea whale fall communities.

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