期刊
MARINE DRUGS
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md17010056
关键词
nitrogenous terpenoids; South China Sea; sponge; nudibranch; cytotoxicity
资金
- National Key Research and Development Program of China [2018YFC0310903]
- National Natural Science Foundation of China (NSFC) [81520108028, 41676073]
- NSFC/CNRS joint project [81811530284]
- SKLDR/ SIMM Project [SIMM1705ZZ-01]
- Youth Innovation Promotion Association from the Chinese Academy of Sciences [2016258]
- SA-SIBS Scholarship Program
- MIUR-ITALY PRIN2015 [2015MSCKCE_004]
A detailed chemical investigation of two South China Sea nudibranchs Phyllidiella pustulosa and Phyllidia coelestis, as well as their possible sponge-prey Acanthella cavernosa, led to the isolation of one new nitrogenous cadinane-type sesquiterpenoid xidaoisocyanate A (1), one new naturally occurring nitrogen-containing kalihinane-type diterpenoid bisformamidokalihinol A (16), along with 17 known nitrogenous terpenoids (2-15, 17-19). The structures of all the isolates were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported axiriabiline A (5) was determined by X-ray diffraction (XRD) analysis. In a bioassay, the bisabolane-type sesquiterpenoids 8, 10, and 11 exhibited cytotoxicity against several human cancer cell lines.
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