期刊
MARINE DRUGS
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md17010046
关键词
Penicillium; citrinin dimer; antibacterial; cytotoxic
资金
- Natural Science Foundation of Fujian Province [2018J01064]
- Foundation of Third Institute of Oceanography SOA [2018021, 2017001]
- COMRA program [DY135-B2-05, DY135-B2-01]
Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3-13). A plausible biogenetic pathway for compounds 2-4 was proposed. Their structures, including absolute configurations, were established through analysis of extensive spectroscopic data and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 1 and 2 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 5 and 10 displayed relatively stronger activities than the other compounds against Vibrio vulnificus and Vibrio campbellii. Compound 1 showed the most potent cytotoxic activity towards the HeLa cell.
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