期刊
MARINE DRUGS
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md17010012
关键词
NdgR(yo); IclR family regulator; Streptomyces; fatty acid amide; genome mining
资金
- National Natural Science Foundation of China [31570032, 31711530219, 41506157, 21502180]
- NSFC-Shandong Joint Foundation [U1706206, U1406403]
NdgR(yo), an IclR-like regulator, was selected as the target gene to activate new secondary metabolites in the marine-derived Streptomyces youssoufiensis OUC6819. Inactivation of the ndgR(yo) gene in S. youssoufiensis OUC6819 led to the accumulation of a new fatty acid amide (1), with an unusual 3-amino-butyl acid as the amine component. Moreover, its parent fatty acid (2) was also discovered both in the wild-type and ndgR(yo) mutant strains, which was for the first time isolated from a natural source. The structures of compounds 1 and 2 were elucidated by combination of LC-MS and NMR spectroscopic analyses. This study demonstrated that the ndgR(yo) homologs might serve as a target for new compound activation in Streptomyces strains.
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