期刊
MARINE DRUGS
卷 16, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/md16110440
关键词
sediment-derived fungus; Aspergillus wentii; 20-nor-isopimarane epimers; antimicrobial activity
资金
- National Key R&D Program of China [2018YFC0310800]
- National Natural Science Foundation of China [31700043]
- Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14]
Four new uncommon 20-nor-isopimarane diterpenoid epimers, aspewentins I-L (1-4), together with a new methylated derivative of 3, aspewentin M (5), were isolated from the deep sea sediment-derived fungus Aspergillus wentii SD-310. The very similar structures of these epimers made the separation and purification procedures difficult. The structures of compounds 1-5 were illustrated based on spectroscopic analysis, and the absolute configurations of compounds 1-5 were unambiguously determined by the combination of NOESY, time-dependent density functional (TDDFT)-ECD calculations, and X-ray crystallographic analysis. These metabolites represented the rare examples of 20-nor-isopimarane analogues possessing a cyclohexa-2,5-dien-1-one moiety. These compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria, as well as plant-pathogenic fungi. While compounds 1 and 2 exhibited inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio harveyi, and V. parahaemolyticus, compound 5 showed potent activity against the plant pathogen Fusarium graminearum.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据