期刊
MARINE DRUGS
卷 17, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md17010026
关键词
Crinoid; feather star; Capillaster multiradiatus; naphthopyrones; pyrano[2; 3-f]chromene; capillasterin A; HIV-1
资金
- Australian Research Council (ARC) [LE0668477, LE140100119, LE0237908]
- Canadian Institutes for Health Research [CIHR PJT-153057]
- Griffith University-Simon Fraser University Collaborative Travel Grant
Capillasterin A (1), a novel pyrano[2,3-f]chromene, together with seven known naphthopyrones including comaparvin (2), TMC-256C1 (3), 6-methoxycomaparvin-5- methyl ether (4), 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (5), 5,8-dihydroxy-6,10-dimethoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (6), TMC-256A1 (7) and 6-methoxycomaparvin (8) were isolated from an EtOH/H2O extract from the Australian crinoid Capillaster multiradiatus. The structures of all the compounds were determined by detailed spectroscopic (1D/2D NMR and MS) data analysis. This is the first report of a natural product that contains the pyrano[2,3-f]chromene skeleton. Compounds 2-6 were observed to display moderate inhibition of in vitro HIV-1 replication in a T cell line with EC50 values ranging from 7.5 to 25.5 mu M without concomitant cytotoxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据