期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1848, 期 11, 页码 3089-3100出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2015.05.022
关键词
Antimicrobial peptides; Resistance; Surface; Biophysical properties; Biochemical properties; Biofilm; Cross resistance
资金
- Conseil Pasteur-Weizmann
- Israel Ministry of Health (IMOH) [3-7291]
- German Israel Foundation (GIF) [1015-264.2/2008]
- European Community's Seventh Framework Programme (FP7) [278998]
Multidrug resistance bacteria are a major concern worldwide. These pathogens cannot be treated with conventional antibiotics and thus alternative therapeutic agents are needed. Antimicrobial peptides (AMPs) are considered to be good candidates for this purpose. Most AMPs are short and positively charged amphipathic peptides, which are found in all known forms of life. AMPs are known to kill bacteria by binding to the negatively charged bacterial surface, and in most cases cause membrane disruption. Resistance toward AMPs can be developed, by modification of bacterial surface molecules, secretion of protective material and up-regulation or elimination of specific proteins. Because of the general mechanisms of attachment and action of AMPs, bacterial resistance to AMPs often involves biophysical and biochemical changes such as surface rigidity, cell wall thickness, surface charge, as well as membrane and cell wall modification. Here we focus on the biophysical, surface and surrounding changes that bacteria undergo in acquiring resistance to AMPs. In addition we discuss the question of whether bacterial resistance to administered AMPs might compromise our innate immunity to endogenous AMPs. This article is part of a Special Issue entitled: Bacterial Resistance to Antimicrobial Peptides. (C) 2015 Published by Elsevier B.V.
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