期刊
MAGNETIC RESONANCE IN MEDICINE
卷 81, 期 2, 页码 1368-1384出版社
WILEY
DOI: 10.1002/mrm.27471
关键词
connectome; diffusion MRI; ground truth; network; phantom; tractography
资金
- 16 NIH Institutes and Centers [1U54MH091657]
- McDonnell Center for Systems Neuroscience at Washington University
- Australian National Health and Medical Research Council (NHMRC) [1136649]
Purpose: Human connectomics necessitates high-throughput, whole-brain reconstruction of multiple white matter fiber bundles. Scaling up tractography to meet these high-throughput demands yields new fiber tracking challenges, such as minimizing spurious connections and controlling for gyral biases. The aim of this study is to determine which of the two broadest classes of tractography algorithms-deterministic or probabilistic-is most suited to mapping connectomes. Methods: This study develops numerical connectome phantoms that feature realistic network topologies and that are matched to the fiber complexity of in vivo diffusion MRI (dMRI) data. The phantoms are utilized to evaluate the performance of tensor-based and multi-fiber implementations of deterministic and probabilistic tractography. Results: For connectome phantoms that are representative of the fiber complexity of in vivo dMRI, multi-fiber deterministic tractography yields the most accurate connectome reconstructions (F-measure = 0.35). Probabilistic algorithms are hampered by an abundance of false-positive connections, leading to lower specificity (F = 0.19). While omitting connections with the fewest number of streamlines (thresholding) improves the performance of probabilistic algorithms (F = 0.38), multi-fiber deterministic tractography remains optimal when it benefits from thresholding (F = 0.42). Conclusions: Multi-fiber deterministic tractography is well suited to connectome mapping, while connectome thresholding is essential when using probabilistic algorithms.
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