期刊
MAGNETIC RESONANCE IN MEDICINE
卷 81, 期 3, 页码 2184-2194出版社
WILEY
DOI: 10.1002/mrm.27537
关键词
dissolution dynamic nuclear polarization; dry magnet; hyperpolarization; polarizer
资金
- Danish Council for Independent Research [1323-00331B/00331A]
- Danish National Research Foundation [DNRF124]
Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. Method: It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. Results: It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a C-13 liquid state polarization for [1-C-13] pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. Conclusion: We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-C-13] pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.
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