期刊
MAGNETIC RESONANCE IMAGING
卷 56, 期 -, 页码 181-186出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2018.10.007
关键词
-
资金
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development [ZIAHD000266]
- Center for Neuroregenerative Medicine (CNRM) under Henry M. Jackson Foundation (HJF)
The glymphatic system is a recently discovered transport system, mediated by cerebral spinal fluid (CSF), that clears metabolic and cellular waste products in the brain. This system's function in the brain is analogous to that of the lymphatic system in the rest of the mammalian body. It is hypothesized that CSF clears harmful chemicals from the brain by flowing through interstitial spaces in the brain during sleep. While there is growing recognition of the critical role the glymphatic system plays in maintaining normal brain health and in explaining pathology, there are few noninvasive imaging methods that measure and characterize the efficacy of glymphatic transport in vivo. In this study we designed, constructed, and tested a glymphatic transport magnetic resonance imaging (MRI) flow phantom, which combines regions that mimic CSF-filled ventricles and brain interstitial space. We tested high- and low-q space diffusion MRI and diffusion tensor imaging (DTI) acquisitions to determine if they could detect, measure, and map interstitial glymphatic flows. The results suggest that, under certain flow conditions, diffusion weighted MRI can detect the enhanced mixing that occurs during glymphatic clearance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据