期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 33, 页码 21603-21611出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b07642
关键词
indocyanine green (ICG); near-infrared light (NIR); photothermal therapy (PTT); luminescent nanoprobes; persistent luminescence phosphors (PLPs)
资金
- National Natural Science Foundation of China [51373117, 51303126, 51573128, 81402575]
- Tianjin Natural Science Foundation [13JCZDJC33200, 15JCQNJC03100]
Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode has caused strong tissue autofluorescence of the living tissue, which leads to the accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICGi-PLPs)@mSiO(2)) were first designed and prepared for persistent luminescent imaging-guided PTT. The (ICG -PLPs)@mSiO(2) nanocarriers could significantly improve signal-to-noise ratio during luminescence imaging-guided PTT, making the PLP promising for improving the accuracy of the tumor site for photothermal therapy in vivo. This paper is likely to develop a new way for accurately regulating cancer cell death based on luminescence imaging-guided PTT selectively triggered by near-infrared (NIR)-remote.
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