期刊
LEUKEMIA & LYMPHOMA
卷 60, 期 4, 页码 927-933出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2018.1515939
关键词
Hodgkin lymphoma; bleomycin; pulmonary toxicity; prognosis
资金
- Karen Elise Jensen Foundation
- Max and Inger Worzner Foundation
- Foundation in Commemoration of Eva and Henry Fraenkel
- Foundation of Aase and Ejner Danielsen
- Foundation of Poul and Ellen Hertz
- Foundation of Else and Mogens Wedell-Wedellsborg
- A.P. Moller and Chastine Mc-Kinney Moller Foundation for General Purposes
In Hodgkin lymphoma (HL) bleomycin can induce pulmonary toxicity (BPT). BPT consists of respiratory tract symptoms during bleomycin-exposure and radiologic pulmonary lesions without concomitant infection. Older age, bleomycin dose, smoking history and the use of granulocyte-colony stimulating factor (G-CSF) have been suggested as possible risk factors for BPT. It is still debated whether BPT affects overall (OS) and progression-free survival (PFS). We investigated the incidence of BPT along with possible risk factors in 412 HL patients treated in 1990-2014. BPT occurred in 34 patients (8%) and was significantly associated with disseminated disease and B-symptoms. It was more frequent in elderly patients (p = .05) but not significantly correlated with a history of smoking. BPT occurred more often in patients receiving G-CSF (p = .03), particularly the poly-ethylenglycol-bound molecule. All significant risk correlations were limited to the age group >45 years. In the present cohort, BPT did not influence OS or PFS regardless of age.
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