期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 28, 页码 17927-17935出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b05677
关键词
synergistic therapy; periodic mesoporous organosilica; gold nanorods; mesenchymal stem cells; breast cancer
资金
- National Key Basic Research Program of the PRC [2014CB744504, 2011CB707700]
- Major International (Regional) Joint Research Program of China [81120108013]
- National Natural Science Foundation of China [81201175, 81530054, 81371611, 81401469, 81501537]
- Natural Science Foundation of Jiangsu Province [BK20130863]
- National Science Foundation for Postdoctoral Scientists of China [2013T60939, 2012M521934, 2013M542576, 2014T71012]
- Jiangsu Planned Projects for Postdoctoral Research Funds [1301023A]
- Research Program of Jinling Hospital [2014054]
Mesenchymal stem cells (MSCs) have attracted increasing attention as vehicles for cancer treatment. Herein, MSC-based synergistic oncotherapy strategy is presented for the first time. To achieve this goal, yolk shell structured gold nanorod embedded hollow periodic mesoporous organosilica nanospheres (GNR@HPMOs) with high paclitaxel (PTX) loading capability and excellent photothermal transfer ability upon near-infrared (NIR) light irradiation are first prepared. Cytotoxicity and migration assays show that the viability and tumor-homing capability of MSCs are well-retained after internalization of high content of PTX loaded GNR@HPMOs (denoted as GNR@HPMOs-PTX). In vitro experiments show the GNR@HPMOs-PTX loaded MSCs (GNR@HPMOs-PTX@MSCs) possess synergistic chemo photothermal killing effects for breast cancer cells. Also, photoacoustic imaging shows that the MSCs can improve dispersion and distribution in tumor tissue for GNR@HPMOs-PTX after intratumoral injection. In vivo experiments in breast cancer model of nude mice further demonstrate that the GNR@HPMOS-PTX@MSCs significantly inhibit tumor growth, suggesting their great potential for synergistic therapy of cancer.
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