期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 42, 页码 28522-28528出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b10498
关键词
antibacterial adhesion; poly(methyl methacrylate); borneol; copolymer; implant
资金
- National Natural Science Foundation of China [21204004, 21574008]
- Fundamental Research Funds for Central Universities of China [YS1407]
- BUCT Fund for Disciplines Construction and Development [XK1538]
Poly(methyl methacrylate) (PMMA) is a widely used biomaterial. But there is still a challenge facing its unwanted bacterial adhesion because the subsequent biofilm formation usually leads to failure of related implants. Herein, we present a borneol-modified PMMA based on a facile and effective stereochemical strategy, generating antibacterial copolymer named as P(MMA-co-BA). It was synthesized by free radical polymerization and studied with different ratio between methyl methacrylate (MMA) and borneol acrylate (BA) monomers. NMR, GPC, and EA, etc., were used to confirm their chemical features. Their films were challenged with Escherichia coli (Gram-negative) and Bacillus subtilis (Gram-positive), showing a BA content dependent antibacterial performance. The minimum effective dose should be 10%. Then in vivo subcutaneous implantations in mice demonstrated their biocompatibilities through routine histotomy and HE staining. Therefore, P(MMA-co-BA)s not only exhibited their unique antibacterial character but also suggested a potential for the safe usage of borneol-modified PMMA. frame and devices for further implantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据